“This is the first detailed study of how and where ORC regulates epigenetics and gene expression in human cells,” said Anindya Dutta, Ph.D., leader of the study and chair of the University of Alabama ...

Inside every cell, thousands of molecular signals collide, overlap, and compensate, obscuring the true drivers of gene ...

A research team has identified the core gene expression networks regulated by key proteins that fundamentally drive phenomena such as cancer development, metastasis, tissue differentiation from stem ...

Origin-recognition complex, or ORC, plays an unexpectedly broad role in the regulation of human cell gene expression, according to a study in the journal Cell Reports. This is the first detailed study ...

KYOTO – An international team of researchers has taken an important step toward understanding how gene expression is controlled across the human genome. A new study has comprehensively analyzed ...

In biology classrooms, we often learn that genes are transcribed into mRNA, which is then translated into proteins—a tidy, linear process. But gene expression in living cells is far more intricate, ...

Although HPVs do express some unspliced mRNAs (Figure 2), most HPV mRNAs are the products of constitutive and alternative splicing. Constitutive splicing is where every intron in the primary RNA ...

Oregon Health & Science University has a leading role in a new database designed to track the normal expression of genes in organs and tissues from prenatal development through adulthood. Researchers ...

Human DNA constantly refolds in 3D space, and these looping dynamics regulate gene expression and cell identity.

This is the first detailed study of how and where ORC subunits regulate epigenetics and gene expression in human cells. “This is the first detailed study of how and where ORC regulates epigenetics and ...